Method glossary

hard outcome

Event that matters to the patient (heart attack, death, fracture) — not an intermediate marker.

Source

BEST (Biomarkers, EndpointS, and other Tools) Resource — Glossary
FDA-NIH Biomarker Working Group. Silver Spring (MD)/Bethesda (MD): FDA e NIH; atualizado continuamente. NCBI Bookshelf NBK338448
https://www.ncbi.nlm.nih.gov/books/NBK338448/

Where, in the source

Glossary — the clinical outcome and surrogate endpoint entries

Checked at the source on

2026-08-10

Verbatim

The official passage from this source is transcribed and checked in our own method document, with the date of verification.

Who wrote this

The wording of this entry is ours, written for people outside the field. The concept and its limits come from the source above, against which this wording is checked — it is neither a translation nor a copy of it.

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